Many of the symptoms older adults are told to accept as part of aging have causes that can be measured.
Research presented at the 2026 meeting of the American Academy of Allergy, Asthma and Immunology sharpened a point that senior care teams encounter regularly. Analyzing an anaphylaxis registry of more than 1,000 patients treated across 40 hospitals, investigators found that a cofactor, most often exercise, was implicated in roughly half of adult cases of food-induced anaphylaxis, with alcohol and NSAIDs among the leading contributors. The takeaway is that an adult's reaction to a food is rarely fixed. The same meal can pass without incident one day and trigger a serious reaction the next, depending on what else is happening in the body.
Fatigue, skin irritation, digestive trouble, and respiratory discomfort are often filed under "just getting older." In a meaningful number of cases they are something more specific and more addressable: a food the body has started reacting to. Integrated Senior Foundation has launched a Nutritional Food Sensitivity Awareness Program, offered at no cost to every resident across ISF-owned communities and those managed by its operating partner, Insight Living. Delivered in partnership with Precision Point Diagnostics and supported by Integrated Senior AI (ISAI), the program reflects how the Foundation approaches aging: as a question to be measured rather than guessed at, with each resident's results feeding a continuous, consented picture of their health rather than a one-time test that sits in a file.
Food reactions are not a childhood condition
Food reactions are not limited to children. Nearly half of U.S. adults with food allergies develop them in adulthood, with an estimated prevalence of ≈8.8–9% among seniors [1–3]. Compounding this, up to 65% of U.S. adults aged 65+ take multiple medications, increasing the likelihood of food–drug interactions and cofactors such as NSAIDs, which play a role in as many as 25% of food-induced anaphylaxis cases [4–5]. Meanwhile, 36% of Americans experience lactose malabsorption, and ≈1% live with undiagnosed celiac disease [6–7]. Taken together, these figures make the case for early, objective testing: clarifying whether a symptom stems from an allergy or an intolerance is the first step toward personalizing a resident's diet and safeguarding their health.
Why screening matters later in life
Residents reasonably ask why testing is worthwhile after a lifetime of eating the same foods. The answer is that sensitivities are not fixed: age, new health conditions, and prescription medications can change how the body responds, turning a once-minor reaction into a disruptive one. Medications can also influence both the presentation and the severity of a sensitivity. NSAIDs (ibuprofen, aspirin) can increase gut permeability, while beta-blockers may reduce the effectiveness of emergency epinephrine in severe reactions [8–9]. Combined with polypharmacy and the natural changes in an aging immune system, testing for IgE sensitization becomes an essential part of safe senior care rather than an optional extra.
What residents receive
IgE testing is widely recognized as the standard for uncovering immune reactivity to food allergens, and it surfaces sensitivities that would otherwise be overlooked [3]. Each participating resident receives a clear report on their reactions to 88 foods, sorted into three categories:
No Limitation
Rotate
Eliminate
For many residents, the results finally explain symptoms that have persisted for years, and they translate directly into action. Over time, ISF plans to connect these results with ingredient-level data from its meal tracking system to refine dining options and strengthen resident safety.
How the program works
Through Precision Point Diagnostics, ISF delivers a validated IgE test that is simple, private, and informative. Results give residents and their care teams the information needed to adjust diets and medication plans in ways that reduce risk and support better daily living. ISAI handles the data integration, turning individual test results into care insights that can be applied consistently across assisted living and memory care communities.
The clinicians involved frame the value in practical terms.
"Residents sometimes assume that discomfort or new symptoms are just a normal part of aging," said Bryan Ziebart, CEO of Insight Living and a partner with ISF. "With this program, we can identify hidden sensitivities and give residents clear information they can use to feel better every day."
Yasaman Fatapour, PhD, pointed to the medication dimension. "Accurate IgE data for seniors on multiple medications is crucial. It lets clinicians identify risks, adjust prescriptions, and refine dining plans to prevent triggers, ultimately improving safety."
Monica Chapman, RN, BSN, added a care-team view. "I'm excited about the free sensitivity testing. This helps us customize meals and medications with real data. Even inactive ingredients in prescriptions can cause issues. Understanding these sensitivities helps us avoid unnecessary side effects."
Where this fits in ISF's research model
The screening is one input into a deliberately deep approach to resident data. Rather than tracking a wide population at a shallow level, ISF gathers many measurements per resident over time, across areas like sleep, vitals, mobility, nutrition, and cognition, so that a single finding such as a food sensitivity can be read in the context of the whole person. Researchers describe this kind of dense, per-individual measurement as deep phenotyping, and it is what gives the data its value for understanding how people age.
That approach only works if residents trust it. Participation is voluntary, and resident data is handled under the same privacy, consent, and governance standards that guide every ISF program. The aim is not surveillance but clarity: information residents and their care teams can act on, and that, with consent, contributes to a body of real-world evidence that can improve care for others over time.
Participation
The program is available at no cost to all eligible residents, and participation is voluntary. Those interested can take part by contacting their Executive Director, who can provide details on the screening and the next steps.
When a symptom is treated as an unavoidable part of growing older, it stops being investigated. Replacing that assumption with a simple, objective test changes what care teams can see and what they can do about it. That shift, from accepting symptoms to measuring their cause, is the reason ISF screens every resident rather than waiting for a reaction to force the question. Multiplied across every resident who opts in, a program that helps one person feel better at dinner also builds the kind of evidence that can sharpen how an aging population is fed and cared for.
Sources:
Featured study: Sato, S., et al. (2026). Cofactors in food-induced anaphylaxis among children and adults, drawn from a Japanese anaphylaxis registry (2022–2024). Presented at the 2026 AAAAI Annual Meeting; Journal of Allergy and Clinical Immunology. https://www.jacionline.org/article/S0091-6749(25)01772-5/fulltext
Wang, J., & Sampson, H. A. (2019). Food allergy in older adults: epidemiology and challenges. Curr Opin Allergy Clin Immunol, 19(3), 210–216. https://doi.org/10.1097/ACI.0000000000000520
Warren, C. M., Jiang, J., & Gupta, R. S. (2021). Epidemiology and burden of adult-onset food allergy. J Allergy Clin Immunol Pract, 9(4), 1656–1665. https://doi.org/10.1016/j.jaip.2020.11.005
Gupta, R. S., et al. (2019). Prevalence and severity of food allergies among US adults. JAMA Netw Open, 2(1):e185630. https://doi.org/10.1001/jamanetworkopen.2018.5630
Kantor, E. D., et al. (2015). Trends in prescription drug use among adults in the United States from 1999–2012. JAMA, 314(17):1818–1831. https://doi.org/10.1001/jama.2015.13766
Worm, M., et al. (2018). NSAIDs as cofactors in food-induced anaphylaxis. Allergy, 73(8):1561–1572. https://doi.org/10.1111/all.13461
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Lactose intolerance. Reviewed March 2023. https://www.niddk.nih.gov/health-information/digestive-diseases/lactose-intolerance
Rubio-Tapia, A., et al. (2012). The prevalence of celiac disease in the United States. Am J Gastroenterol, 107(10):1538–1544. https://doi.org/10.1038/ajg.2012.219
Maseda, D., & Ricciotti, E. (2020). NSAID–Gut Microbiota Interactions. Front Pharmacol, 11:1153. https://doi.org/10.3389/fphar.2020.01153
Devlin, H. (2022). Food hypersensitivity in adults much more common than thought. The Guardian. https://www.theguardian.com/society/2022/dec/19/food-hypersensitivity-adults-more-common-uk


